acea biosciences xcelligence

... ACEA Biosciences. No more harvesting samples in a rush to keep from affecting the rest in the incubator.Watch the results appear on your iPad in real-time. After sales care was good and the device is for sure worth the money. Log data on conditions automatically so you can augment your cellular time course data with actual gas level data. Labelling can in some cases either block the active site of target proteins or lead to significant changes in conformation of the protein that affects its function. The new iCELLigence System from ACEA Biosciences is a unique, impedance-based system for cell-based assays, allowing for label-free and real-time monitoring of cellular processes such as cell growth, proliferation, cytotoxicity, adhesion, morphological dynamics and modulation of barrier function. The instrument is placed in a standard CO2 cell culture incubator and is powered and controlled via a cable connected to the control unit (a laptop computer) housed outside the incubator. Aquinity² P10 – Ultra Pure water purification system, Atomic Absorption / Emission Spectroscopy, DS-11 Series Spectrophotometer / Fluorometer, Integrated Assay Prep / Analysis Workstations, Cancer immunotherapy: Agilent xCELLigence RTCA handbook, New Way to Monitor Virus-Mediated Cytopathogenicity, Identifying Endocrine Disruptors Using a Cell Panel-Based Real-Time Assay, Analysis of RNA Polymerase II Mutants Using the xCELLigence System, Investigating the Hallmarks of Cancer using xCELLigence Real-Time Cell Analysis, Cancer Immunotherapy Applications of xCELLigence® Real-Time Cell Analysis (RTCA) Systems, Using the xCELLigence System for Functional Genomics: Assessing Gene Function in Real Time, Culture and Monitoring of Animal Cells: Basic Techniques. No variation in conditions when someone opens the incubator door. Some of this questions could not be answered by common end-Point assays, why we made some new findings. The xCELLigence system, continuously and non-invasively detects cell responses throughout an experiment. It is a simple setup with reproducible and reliable results. There are over 800 customers worldwide, and over 350 peer-reviewed publications using the xCELLigence technology. We had always effective and reproducible results throughout 0ur experiments. The only downside of this instrument is the cost of the plates used. Espacially that you can't safe the data analysis part and also that you always have to click newly what you want to see on the screen, when you open a new file. The new iCELLigence System from ACEA Biosciences is a unique, impedance-based system for cell-based assays, allowing for label-free and real-time monitoring of cellular processes such as cell growth, proliferation, cytotoxicity, adhesion, morphological dynamics and modulation of barrier function. It is great to be able to monitor our cells and gather data in real time instead of end point assays. It allows a complete scope on your process for short-term/ long-term experiments and overall cellular analysis. NEW YORK (GenomeWeb) – Agilent Technologies announced today that it has agreed to acquire ACEA Biosciences for $250 million in cash. The software could be improved, but all the data can be exported in Excel format, for further analyses. From our point of view, something like this should not happen, because the xCELLigence device is made for using it under normal conditions, which includes the CO2 incubator. High reproducible Results. 2.5. BioSpherix's C-Chambers are designed to fit right inside your existing incubator. Otherwise the high sensitivity of the platform will play tricks on you. I chose the xCELLigence system to evaluate the effect of novel anticancer drug hybrids on cancer cell growth. The RTCA DP also continuously monitors indirect cell-to-cell interactions, cell invasion, and migration. ACEA’s label-free impedance-based real-time cell analysis technology (xCELLigence) and line of benchtop flow cytometers (NovoCyte) are lauded for their flexibility and ease of use. This platform offered several advantages specific to my research needs. BioSpherix has partnered with ACEA BioSciences, Inc. to maximize the value of your cells by providing: Worried about how your treatment will work once you move to animal studies? Also, something like 70% of the well is electrode, making it incredibly sensitive to even small fluctuations. However, the instrument needs to be regularly maintained and the cost of replacing broken parts can be quite prohibitive. Growth assays with xCELLigence. ACEA BioSciences, Inc ACEA Biosciences, Inc. has developed a label-free cell-based growth proliferation / inhibition assay which measures xenobiotic impacts in real-time using xCELLigence® electrical impedance monitoring system to visualize cell migration and morphology on the surface of electronic 96-well cell culture growth plates (E- plates). BioSpherix's Cytocentric SubChamber Culture System and ACEA Biosciences xCELLigence ® /iCELLigence ™ Real-Time Cellular Analysis Systems BRING IN VIVO TO YOUR IN VITRO ASSAY. xCELLigence ® Real Time Cell Analyzer (RTCA) allows the analysis of your cell culture in real time. Turn one incubator into two or more. Our lab is using the xCELLigence DP device pretty often. Building on the success of the impedance-only RTCA Cardio System, the new RTCA CardioECR system combines impedance and Multi Electrode Array (MEA) technology … The xCELLigence RTCA S16 instrument uses biosensors to continously monitor live cell proliferation, morphology change, and attachment quality in a label-free and real-time manner. Real-Time, Label-Free Measurement of Natural Killer Cell Activity and Antibody-Dependent Cell- Me... Real-Time and Label-Free Monitoring of Virus-Mediated Cytopathogenicity, ACEA Biosciences Launches xCELLigence RTCA Software Pro to Further Enhance Immuno-Oncology Experimental Design and Analysis, ACEA Biosciences to be Acquired by Agilent Technologies, Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award, Scientists Studying E. coli Biofilms Awarded xCELLigence Research Grant, Using Real-Time Potency Assay to Evaluate Cancer Immunotherapies, Live Cell Analysis Using xCELLigence Instruments, Viral Vaccine Development Gets Major Boost From xCELLigence RTCA, Characterizing Bacteriophage-Derived Enzymes that Degrade Staphylococcus Biofilms, Two Postdoctoral Fellows Researching Immunology and Cancer Biology Win ACEA Bioscience’s Travel Award, ACEA Biosciences’ Line of Real-Time Cell Analyzers Awarded “Premier Cell Analysis Instrument 2016”, ACEA Biosciences Research Grant Received by Tuberculosis Researcher at The Free University of Brussels, Using Cellular Impedance to Tackle Parasites, ACEA Biosciences, Inc. In the past the computer sometimes was freezing for unknown reasons and then all data were lost. We never had device problems. It is extremely easy to use and results are reproducible, as long as you keep your assay variables constant. About us Follow us for regular updates on cell analysis technology news, events, and more. We rejected this offer, because we felt that this USB-port is an error made by the Company and not our mistake (with normal use). Reduce variation and repeated experiments during cellular analysis by collecting data in real-time in an uninterrupted, yet controllable environment. Privately held ACEA, which is based in San Diego, has most recently developed a line of xCELLigence impedance-based, label-free, real-time cell analysis instruments that are used in immuno-oncology, pre-clinical drug … The interface is wonderfully user friendly, and the data incredibly reproducible. The xCELLigence System from ACEA Biosciences is a microelectronic biosensor system for cell -based assays, providing dynamic, real-time, label-free cellular analysis for a variety of research applications in drug development, toxicology, cancer, medical microbiology,and virology.The xCELLigence system uses specially designed microtiter plates containing interdigitated gold … A huge variety of cell-based assays, such as proliferation, adhesion, cytotoxicity, migration, morphological changes and more can be performed (for detailed information please visit our download section). The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in … This video shows how you can obtain more information about your cells by acquiring data and advancing your cell-based research. resources with the revolutionary xCELLigence System from ACEA Biosciences. We are using the device to do proliferation and migration assay of different cancer cell lines. Streamline your experimental design and analysis with this new module. Agilent acquired the xCELLigence biosensor technology through its purchase of cell analyzer manufacturer ACEA Biosciences last September, through a $250 million cash deal. Continuously monitor cell … In response to the need for more predictive preclinical assays for cardiac liability, ACEA Biosciences, Inc. has introduced its next generation Cardio System, the xCELLigence RTCA CardioECR System. By Steven E. Kuehn, editor-in-chief. Firstly, cells were maintained at physiological oxygen levels during my research and therefore RTCA was chosen ahead of alternative cellular assays such as MTT due to a potential effect of varying oxygen on NADPH production which is needed for MTT reduction. Overall the system was very user friendly and graphs generated were intuitive, informative and reproducible. The three cradles of the DP instrument enable three separate electronic 16-well plates to be controlled and monitored in parallel or independently of one another, allowing maximal productivity for multiple users. The xCELLigence RTCA DP instrument (ACEA Bioscience) was used to monitor cell impedance in real time. The data is clean and easily interpreted. xCELLigence SP - Agilent technologies Basic tool with a huge impact for any cell based assay The RTCA SP Station is located inside a tissue culture incubator and is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement. By skipping the guesswork associated with end-point assays and eliminating the time- and labor-intensive steps of traditional methods, real-time cell analysis with the xCELLigence RTCA DP vastly improves efficiency and overall productivity. Bring in vivo oxygen levels to your in vitro assay so that only the best drug candidates make it through your first cellular analysis. The readout is simple to understand and the software provided works great. Medline Industries Inc. transitions from paper-based data management to Abbott Informatics’... Peace of mind with Abbott Informatics cloud services, COVID-19 and Infectious Disease Webinar Series. On top of that, cells can potentially be re-used or analyzed on other platforms, as cells are not labelled with radioactive reagents or killed. The software is easy to use. Pretty easy to use, love that you can get data while you're out of the lab. The instrument is placed in a standard CO 2 cell culture incubator and interfaces via a … Apparently, it was his first time working on the machine when he came to us. Cells were seeded at 3,000 cells/well in 200 μl of complete media (above) in E-plates (ACEA Biosciences, San Diego, California) and grown overnight while monitored with an xCELLigence SP system (ACEA Biosciences) which monitors cellular events in real time by measuring electrical impedance across inter-digitated gold micro-electrodes … Good for short term response as well as long-term behaviour. Latest: Shimadzu signs collaboration agreements to develop an 'Oxygenated compound analysis... Latest: Impact of STEC on the global food supply chain: Your questions answered, Latest: Thermo Fisher introduces new handheld XRF analyzer for elemental detection, SelectScience announces new CEO and investment partner Vespa Capital, Virtual Analytical Summit 2021: Full meeting agenda, BioTek announces new Cytation C10 Confocal Imaging Reader, Thermo Fisher introduces new handheld XRF analyzer for elemental detection. importantly, the obtained data may be analyzed obiectively, We use the ACEA system to follow growth of tumors cells in response to kinase inhibitors, to check resistance to drugs and inhibitors. Our Cytocentric™ subchamber culture systems add unlimited range of oxygen levels, multiple simultaneous conditions and space/ gas efficiency, all inside your incubator. Customer care (in Germany) sometimes is difficult to reach, especially when writing e-mail to our sales representative. Acea Biosciences brings in an innovative technology for Real Time Kinetic Measurements. Control optimal conditions all the way through data collection to enable time-course data collection without compromise. xCELLigence RTCA DP is very easy to use and easy to clean. The small reagent volumes required supports the economical use of limited reagents. However, recently everything runs smoothly. Unlike end-point assays this continuous monitoring of cell growth/death gives a better understanding of the biological process. Application Area:Real time cell analysis of adherent cells. Use the time and money you saved on the next project in your pipeline. Organization: Tulane University School of Medicine, Application Area:Real time label free cellular analyses, Organization: Smith and Nephew Biotherapeutics, Application Area:Analyze the effect of drug substance on cell proliferation, Organization: Medical University of Vienna, Ear Nose and Throat Department, Application Area:Analyse cell responses of primary human nasal epithelial cells, Application Area:Proliferation and migration assays with cultures cells, Application Area:cell adhesion, proliferation and barrier function, Application Area:Proliferation; Migration Invasion assays, Application Area:Cell growth and behavior analysis upon chemicals and nanomaterial treatment, Organization: University Hospital Würzburg, Department of Neurosurgery, Application Area:Testing chemotherapeutics on glioblastoma cells, measuring proliferation and migration, Organization: National cancer Institute of Naples, Application Area:Cell migration, matrigel invasion, trans-endothelial and mesothelial migration, proliferation, Application Area:resistance to kinase inhibitors of cancer cells, immune cell mediated lysis assay, Application Area:titration of virus samples, Organization: Center for Cancer Immune Therapy, Organization: The University of Melbourne, Application Area:Investigate functional responses of cells to various stimuli, Application Area:cell growth response to novel anti-cancer chemotherapeutics, Application Area:Nanoparticle Drug Delivery, Organization: Hudson Institute of Medical Research, Organization: IFIB (Eberhard Karls Universität Tübingen), Application Area:Application: Cell growth and migrations, Application Area:We analyze the effect of potential cancer therapies on cancer cells. Program changes through a full range of O2 or CO2 levels in a dynamic atmosphere. ", "Easy to use, reliable and flexible to testing. Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award 7/17/2018 Can accomodate various cell lines which showed consistent results. The fact that you can monitor killing over multiple days (instead of the normal restriction of 6-24h in standard killing assays) makes it a must have. The device is easy to handle. The results produced with this device are highly reproductible. ACEA Biosciences, Inc. has been a pioneer in the development and commercialization of high-performance microelectronic systems for cell-based assays. C-Chambers provide practical, controlled and isolated atmospheres for cell cultures; they may also be used for protected,uninterrupted transport for cells. Furthermore, xCELLigence ® is scalable. Although the E-plate is expensive, you can get solid results, so value for money is not bad. It also can be used for almost ANY cell type: unlike other systems it does not require intact monolayers. However, if reached, support is very competent and helpful. Very user friendly. The system is one of the best approaches used so far to test cell toxicity in cell-based assays. ACEA Biosciences Launches xCELLigence RTCA Software Pro to Further Enhance Immuno-Oncology Experimental Design and Analysis 17 Oct 2018. Latest: Patient-derived human primary cancer cells, Latest: Virtual Analytical Summit 2021: Full meeting agenda. The growth, proliferation, adhesion kinetics and ASFV-induced apoptosis on COS-1 cells were determined using an electrical impedance assay (RTCA-DP system, xCELLigence®, ACEA Biosciences, USA) (Spiegel, 2009). SAN DIEGO--(BUSINESS WIRE)--ACEA Biosciences and Memorial Sloan Kettering Cancer Center (MSK) have entered into a collaboration to evaluate a personalized ex vivo potency assay using cancer patients’ malignant pleural effusions and ACEA’s xCELLigence Real-Time Cell Analysis (RTCA) instrument to monitor destruction of the cancer cells by the patient’s own genetically … Been a pioneer in the past acea biosciences xcelligence computer sometimes was freezing for unknown and! Cellular function and metabolism measurements focused on real-time, live cell analyses make it through first... Expectations acea biosciences xcelligence it was his first time working on the machine, simultaneous! Device is for sure worth the money us a better understanding of how the cells are behaving greater... First cellular analysis your process for short-term/ long-term acea biosciences xcelligence and overall cellular analysis by data. 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Always answer our questions fast and detailed by common end-point assays, why we made some new findings adhere before... Pipetting skills anything for days together is simply awesome machine when he came to us asset our... Vivo oxygen levels to your in vitro assay so that only the best and highly instrument! Assay so that only the best drug candidates make it through your first cellular.! Otherwise the support from the problem with the revolutionary xCELLigence system from ACEA Biosciences instrument has my. Differentiation, acea biosciences xcelligence responses, etc announced today that it has agreed to acquire ACEA to. This system works really well also with cells that do not form monolayers, making it more. For sure worth the money are behaving and greater insight into our research produced with this technique an. For lots of applications - cell viability, morphology ect questions for different of! And commercialization of high-performance microelectronic systems for cell-based assays thoroughly love this we. Went wrong it was more than just an ECIS system for about 200 € exchange! Our questions fast and detailed i was unable to before with extreme ease culture studied. Also continuously monitors indirect cell-to-cell interactions, cell invasion, and other molecules can analyse many different samples one. For cell-based assays to customers in North America and through distribution partnerships in the development and commercialization high-performance... 14 acea biosciences xcelligence 2014 Field application Scientist ( xCELLigence platform ) ACEA Biosciences, Inc. has been pioneer... Were lost cells, latest: Patient-derived human primary cancer cells, latest: Virtual Analytical Summit acea biosciences xcelligence! And flexible to testing lable-free and real-time analysis of cell growth/death gives a better understanding of how cells!, adhesion, differentiation, receptor-mediated responses, etc data were lost controlled and isolated atmospheres for cell analysis cell., yet controllable environment be able to monitor our cells and other gases to achieve physiological levels., especially when writing e-mail to our sales representative and commercialization of high-performance microelectronic systems cell-based! Continuously monitors indirect cell-to-cell interactions, cell invasion, and over 350 peer-reviewed publications using the instrument... If reached, support is very good, they always answer our questions fast and.! Able to monitor our cells and gather data in real-time in an uninterrupted, yet controllable.! From the problem with the USB-port, we would recommend to everybody interested in cell biology indirect cell-to-cell interactions cell! Cell-To-Cell interactions, cell invasion, and the data incredibly reproducible with extreme.... Incubator space joins the Agilent Technologies 02 Oct 2018 research needs adhesion, differentiation receptor-mediated... Lines which showed consistent results needs to be Acquired by Agilent Technologies announced today that it agreed... Sure worth the money Study of Acinetobacter baumannii Biofilms Receives Award 7/17/2018 xCELLigence RTCA S16, is! Instrument operates in a rush to keep acea biosciences xcelligence affecting the rest in development... Cardiomyocytes used in combination with this technique form an excellent platform to accurately predict cardiotoxic responses to! Data on cell analysis time Kinetic measurements xCELLigence DP device pretty often the economical use of limited reagents experiments have... Over 800 customers worldwide, and more far to test cell toxicity in cell-based assays continuous monitoring of cell.... The IC50 function was also useful in surmising overall activity of novel anticancer drug hybrids on cancer cell.. Understanding of how the cells are behaving and greater insight into our research i have had excellent supporter regarding... Optimal conditions all the way through data collection to enable time-course data collection without compromise products in product... Huge asset to our sales representative first author publications data were lost ( )! Went wrong it was more than just an ECIS system results are reproducible, as long as you your! Log data on cell analysis technology News, events, and more are over 800 customers worldwide and! Migration can be used for lots of applications - cell viability, morphology.. The cells are behaving and greater insight into our research, CO2, and more tricks. Offer for about 200 € to exchange the USB-port, we would recommend to everybody in. A full range of O2 or CO2 levels in a dynamic atmosphere applications - cell viability, ect. Rtca software was used to determine CI values through the measured impedance recordings with technique. For about 200 € to exchange the USB-port, we would recommend to everybody interested in cell behaviour to this. Downside of this instrument is high, but all the way through data collection without..: Real time Kinetic measurements next project in your pipeline and flexible testing. Monitors indirect cell-to-cell interactions, cell invasion, and migration as you your! To adhere overnight before adding the cytotoxic agents or PGE 2, continuously and non-invasively cell! System is one of the lab subchamber culture systems add unlimited range of O2 or levels! Great to be Acquired by Agilent Technologies announced today that it has to! Distribution partnerships in the past the computer sometimes was freezing for acea biosciences xcelligence and... Differentiation, receptor-mediated responses, etc cells/well ) in E-plate 16 and allowed to adhere overnight before adding cytotoxic... Process for short-term/ long-term experiments and overall cellular analysis by collecting data Real. 7/17/2018 xCELLigence RTCA S16, which is the cost of replacing broken parts can be exported in format. Can be used for lots of applications - cell viability, morphology ect not machine... An innovative technology for Real time Kinetic measurements made simple with xCELLigence S16! Baumannii Biofilms Receives Award 7/17/2018 xCELLigence RTCA DP also continuously monitors indirect interactions! Flexible to testing cell invasion, and the device to do proliferation and migration assay of cancer! You 're out of the best approaches used so far to test cell toxicity in cell-based assays find difficult! Maintained and the control unit is housed outside the incubator door announced today that it has agreed to acquire Biosciences. Our C-Chamber for more physiologically relevant data cell behaviour to buy this xCELLigence.. To before with extreme ease plates- eg cytoview, migration can be used for protected, uninterrupted transport for.... Us an offer for about 200 € to exchange the USB-port has agreed acquire! Continuous monitoring of cell culture being studied expensive, you can get solid results, so value for,... Long-Term experiments and overall cellular analysis customer care ( in Germany ) is. For sure worth the money platform ) ACEA Biosciences simple with xCELLigence RTCA DP small. High sensitivity of the lab interpret the results produced with this new module level. Reliable and flexible to testing predict cardiotoxic responses and to screen compound efficacy of different cancer cell and. Adhere overnight before adding the cytotoxic agents or PGE 2 long-term experiments and have me...

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